Bovine pancreatic deoxyribonuclease I (DNase I) is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding polynucleotides with free hydroxyl group at the 3′ position and phosphate group at the 5′ position.

The optimum pH is 7.8. DNase I is activated by bivalent metals, and inhibited by chelating agents such EDTA and sodium dodecyl sulfate. DNase I can be stabilized against proteolytic digestion by 5 mM Ca²⁺.

The Deoxyribonuclease I (DNase I) has been chromatographically purified to remove trace contaminating proteases. DNase I may be used in clinic to thin and liquefy mucus in the lungs.

Specification

Activity ≥ 2,000 Kunitz units/mg powder

High quality DNase I
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Storage

Store in an airtight container, at a temperature of 2°C to 8°C

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